Product Name

Manidipine dihydrochloride

General description

Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker.

Synonym

3-[2-(4-benzhydryl-1-piperazinyl)ethyl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate dihydrochloride

Purity

≥99%(HPLC)

CAS Number

89226-75-5

Formula

C³⁵H³⁸N⁴O⁶ · 2HCl

Molecular Weight

683.62

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white to pale yellow solid

Solubility(25℃)

DMSO

≥20mg/mL

Ethanol

Slightly soluble

Water

insolube

l  Biological Information

Biochem/Physiol   Actions

Manidipine dihydrochloride is a hydrochloride salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.

Application

1.      Antihypertensive  Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of   pharmacological mechanism. Among the antihypertensive agents are DIURETICS;

2.      Calcium Channel Blockers

A   class of drugs that act by selective inhibition of calcium influx through cellular membranes.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    https://ncit.nci.nih.gov

2.    https://www.ncbi.nlm.nih.gov