l General Information |
Product Name | Tegafur |
General description | Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. |
Synonym | 5-Fluoro-1-(tetrahydro-2-furyl)uracil; Ftorafur |
Purity | ≥99%(HPLC) | CAS Number | 17902-23-7 |
Formula | C8H9FN2O3 | Molecular Weight | 200.17 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥35mg/mL |
Ethanol | ≥5mg/mL |
Water | ≥5mg/mL |
l Biological Information |
Biochem/Physiol Actions | Tegafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. |
Application | Antimetabolites, Antineoplastic Antimetabolites that are useful in cancer chemotherapy. |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. https://ncit.nci.nih.gov 2. https://www.ncbi.nlm.nih.gov |
