Product   Name

Pramipexole dihydrochloride monohydrate

General   deion

Pramipexole Dihydrochloride is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.

Synonym

(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride; PPX dihydrochloride

Purity

≥99%(HPLC)

CAS   Number

191217-81-9

Formula

C¹⁰H¹⁷N³S · 2HCl · H²O

Molecular   Weight

302.26

Suitability

BioReagent,   suitable for cell culture, etc.

l  Physical and Chemical   Information

Appearance

White   or Off-white solid

Solubility(25℃)

DMSO

≥10mg/mL

Ethanol(96%)

Slightly soluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Pramipexole Dihydrochloride is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3dopamine receptors in the striatum and substantia nigra of the brain. Compared to other dopamine agonists, the use of this agent may be associated with fewer dyskinetic side effects in treated subjects.

Application

1.    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.

2.    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

3.    Drugs that bind to and activate dopamine receptors.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage   temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    https://ncit.nci.nih.gov

2.    https://www.ncbi.nlm.nih.gov