Product   Name

Ropivacaine hydrochloride monohydrate

General   deion

Ropivacaine Hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.

Synonym

(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate

Purity

≥99% (HPLC)

CAS   Number

132112-35-7

Formula

C¹⁷H²⁶N²O · HCl · H²O

Molecular   Weight

328.88

Suitability

BioReagent,   suitable for cell culture, etc.

l  Physical and Chemical   Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥40mg/mL

l  Biological Information

Biochem/Physiol   Actions

Ropivacaine Hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. Ropivacaine binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions and resulting in a stabilization of the neuronal membrane and inhibition of depolarization; nerve impulse generation and propagation are blocked, resulting in a reversible loss of sensation.

Application

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local   anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage   temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    https://ncit.nci.nih.gov

2.    https://www.ncbi.nlm.nih.gov