l General Information |
Product Name | Etomidate |
General deion | Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage. |
Synonym | (R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; R16659; Amidate |
Purity | ≥99% (HPLC) | CAS Number | 33125-97-2 |
Formula | C14H16N2O2 | Molecular Weight | 244.29 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥40mg/mL |
Ethanol | ≥40mg/mL |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia. Etomidate is an imidazole compound that appears to depress CNS function via GABA. Duration of action is intermediate between thiopental and methohexital, and recovery from a single dose is rapid with little residual depression. Like the barbiturates and propofol, etomidate is does not induce analgesia. Etomidate induces unconsciousness within one circulation time. Recovery is rapid as a result of extensive redistribution and rapid metabolism. Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization. |
Application | 1. Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. 2. Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. |
l Packaging & Storage |
Packaging | 50mg; 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
