Product   Name

Sunitinib Malate

General   deion

Sunitinib Malate is a multi-targeted RTK inhibitor. Sunitinib blocks the tyrosine kinase activities of VEGFR2, PDGFRb, and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the   phosphorylation of FLT3.

Synonym

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt;SU011248 L-malate salt

Purity

≥99% (HPLC)

CAS   Number

341031-54-7

Formula

C²²H²⁷FN⁴O²  · C⁴H⁶O⁵

Molecular   Weight

532.56

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical   Information

Appearance

Orange to yellow solid

Solubility(25℃)

DMSO

≥10mg/mL

Ethanol

Very slightly soluble

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Sunitinib Malate is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.

Application

1.    Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

2.    Substances that inhibit or prevent the proliferation of NEOPLASMS

l  Packaging & Storage

Packaging

25mg; 100mg; 500mg

Storage   temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    https://www.   ncit.nci.nih.gov

2.    https://www.ncbi.nlm.nih.gov