Product   Name

Gabapentin HCl

General   deion

Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.

Synonym

1-(Aminomethyl)-cyclohexaneacetic acid hydrochloride

Purity

≥98%(HPLC)

CAS   Number

60142-95-2

Formula

C⁹H¹⁷NO²·HCl

Molecular   Weight

207.7

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Very  slightly soluble

Ethanol

Very  slightly soluble

Water

≥35mg/mL

l  Biological Information

Biochem/Physiol   Actions

Gabapentin,  an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Gabapentin has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn't possess the usual drug interactions.

Gabapentin is a synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant activity. Although its exact mechanism of action is unknown, gabapentin appears to inhibit excitatory neuron activity. This agent also exhibits analgesic properties.

MeSH   Pharmacological Classification

1.    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here..

2.    Agents   that are used to treat bipolar disorders or mania associated with other affective disorders.

3.    Drugs   that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

4.    Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

5.    Drugs used to prevent SEIZURES or reduce their severity.

6.    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

7.    A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage   temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.     http://www.drugbank.ca

2.     https://ncit.nci.nih.gov/

3.     https://www.ncbi.nlm.nih.gov/mesh