Product   Name

Pravastatin sodium

General   deion

Pravastatin sodium is a competitive, water-soluble HMG-CoA reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ～1 nM).

Synonym

(βR,   δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate

Purity

≥98% (HPLC)

CAS   Number

81131-70-6

Formula

C²³H³⁵O⁷Na·xH²O

Molecular   Weight

446.51(anhydrous basis)

Suitability

BioReagent,   suitable for cell culture, etc.

l  Physical and Chemical   Information

Appearance

White solid

Solubility(25℃)

DMSO

≥80mg/mL

Ethanol

≥80mg/mL

Water

≥10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Pravastatin sodium is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase.

Pravastatin Sodium is the sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic   activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.

Application

1.  Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

2.  Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

l  Packaging & Storage

Packaging

250mg; 1g

Storage   temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    S   M Singhvi et.al British journal of clinical pharmacology, 29(29), undefined   (1990-2-1)

2.    Takeshi   Matsuoka et.al Journal of lipid research, 53(53), undefined (2012-6-21)

3.    https://ncit.nci.nih.gov.