Leptomycin B solution from Streptomyces sp.
Product #：
S1412
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S1412-0.5UG
In-stock
93
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S1412-2X0.5UG
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173
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S1412-5X0.5UG
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379
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S1412-10X0.5UG
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594
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S1412-5UG
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Details
l General Information |
Product Name | Leptomycin B solution from Streptomyces sp. |
General description | Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, MPF, IκB, PKA and
MEK. |
Synonym | Leptomycin B; Mantuamycin; |
Purity | ≥95%(HPLC) | CAS Number | 87081-35-4 |
Formula | C33H48O6 | Molecular Weight | 540.73 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Colorless to Light Yellow solution, supplied in methanol: water (7:3) |
l Biological Information |
Biochem/Physiol
Actions | Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region. |
l Storage |
Storage temp. | −20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
