Antipain dihydrochloride from microbial source
Product #:
S1409
Image
SKU-Pack Size
Stock
Price($)
Quantity
-
-
S1409-1MG
In-stock
99
-
+
S1409-5MG
In-stock
154
-
+
S1409-25MG
In-stock
577
-
+
S1409-100MG
In-stock
1746
-
+
Details
l General Information |
Product Name | Antipain dihydrochloride from microbial source |
General description | Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. |
Synonym | N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe |
CAS Number | 37682-72-7 |
Formula | C27H44N10O6· 2HCl | Molecular Weight | 677.62 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Yellow and Faint Beige to Beige Lyophilized Powder |
Solubility(25°C) | DMSO | soluble |
Ethanol | soluble |
Water | ≥35mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. |
Application | Concentrations for 50% inhibition (μg/ml): papain, 0.16 trypsin, 0.26 cathepsin A, 1.19 cathepsin B, 0.59 cathepsin D, 125 plasmin, >93 chymotrypsin and pepsin, >250 It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM |
l Storage |
Storage temp. | −20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |