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Home > Products > Small molecule > Natural products > Antipain dihydrochloride from microbial source

Antipain dihydrochloride from microbial source

Product #: S1409
Image SKU-Pack Size Stock Price($) Quantity
  • S1409-1MG

    In-stock

    99

    - +

    S1409-5MG

    In-stock

    154

    - +

    S1409-25MG

    In-stock

    577

    - +

    S1409-100MG

    In-stock

    1746

    - +

Documents

Details

l  General Information

Product Name

Antipain dihydrochloride from microbial source

General description

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

Synonym

N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe

CAS Number

37682-72-7

Formula

C27H44N10O6· 2HCl

Molecular Weight

677.62

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Yellow and Faint Beige to Beige Lyophilized Powder

Solubility(25°C)

DMSO

soluble

Ethanol

soluble

Water

≥35mg/mL

l  Biological Information

Biochem/Physiol  Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

Application

Concentrations for 50% inhibition (μg/ml):

papain, 0.16

trypsin, 0.26

cathepsin A, 1.19

cathepsin B, 0.59

cathepsin D, 125

plasmin, >93

chymotrypsin and pepsin, >250

It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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