Product Name

β-Amanitin from Amanita phalloides

General description

β-Amanitin belongs to the family of amatoxins.Amanitins are made of bicyclic octapeptides.

Synonym

BETA-AMANITIN; Beta-Amanitin From Amanita Phalloides

Purity

~90%(HPLC)

CAS Number

21150-22-1

Formula

C³⁹H⁵³N⁹O¹⁵S

Molecular Weight

919.95

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Yellow to Brown Powder

l  Biological Information

Biochem/Physiol  Actions

Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

Application

β-Amanitin from Amanita phalloides has been used:

•  as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.

•  to determine its concentration in urine samples by capillary zone electrophoresis (CZE).

•  in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov