Product Name

Nikkomycin Z from Streptomyces tendae

General description

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.

Synonym

Nikkomycin Z; Neopolyoxin C; Nikkomycin

Purity

≥90%(HPLC)

CAS Number

59456-70-1

Formula

C²⁰H²⁵N⁵O¹⁰

Molecular Weight

495.44

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to White w/ Yellow Powder

Solubility(25°C)

Water

~5mg/mL

l  Biological Information

Biochem/Physiol  Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov