Product Name

Streptonigrin from Streptomyces flocculus

General description

Streptonigrin (SN) is an aminoquinone antitumour antibiotic.

Synonym

Bruneomycin, Nigrin

Purity

≥98%(HPLC)

CAS Number

3930-19-6

Formula

C²⁵H²²N⁴O⁸

Molecular Weight

506.46

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Very Dark Red and Very Dark Red-Brown Powder

l  Biological Information

Biochem/Physiol   Actions

Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov