Product Name

Chromomycin A3 from Streptomyces griseus

General description

An antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities.

Purity

≥95%(HPLC)

CAS Number

7059-24-7

Formula

C⁵⁷H⁸²O²⁶

Molecular Weight

1183.25

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow to Yellow-Orange Powder

Solubility(25°C)

Ethanol

≥10mg/mL

l  Biological Information

Biochem/Physiol  Actions

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. It serves as a fluorescent DNA stain. It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

Application

Chromomycin A3 from Streptomyces griseus has been used as a reagent in flow sorting. It has also been used to stain spermatozoa to evaluate the sperm nuclear chromatin integrity.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov