Product Name

Narasin from Streptomyces auriofaciens

General description

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine.

Synonym

Narasin A; Monteban

Purity

≥98%(HPLC)

CAS Number

55134-13-9

Formula

C⁴³H⁷²O¹¹

Molecular Weight

765.03

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to White Yellow w/ Cast Powder

Solubility(25°C)

Ethanol

≥5mg/mL

l  Biological Information

Biochem/Physiol  Actions

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na₊, K₊, and H₊ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H₊ concentration on the inside of the Gram-positive cell. Therefore, the H₊ ATPase pump is activated to transport out excess H₊. The cell is depleted of its energy resources and reduces fermentative functions and cell division.

Application

Narasin is a growth-promoting ionophoric  antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals  and is used in studies involving sodium calcium ion exchange.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov