Product Name

Calphostin C from Cladosporium cladosporioides

General description

Highly specific inhibitor of protein kinase C (IC50 = 50 nM)

Synonym

UCN-1028c

Purity

≥90%(HPLC)

CAS Number

121263-19-2

Formula

C⁴⁴H³⁸O¹⁴

Molecular Weight

790.76

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Red to Black powder

Solubility(25°C)

DMSO

≥1mg/mL

Ethanol

≥1mg/mL

l  Biological Information

Biochem/Physiol  Actions

Highly specific inhibitor of protein kinase C (IC₅₀ = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov