Product Name

Myriocin from Mycelia sterilia

General description

Fungal metabolite with potent immunosuppressant activity.

Synonym

ISP-I, Thermozymocidin

Purity

≥98%(HPLC)

CAS Number

35891-70-4

Formula

C²¹H³⁹NO⁶

Molecular Weight

401.54

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to White Yellow w/ Cast powder

l  Biological Information

Biochem/Physiol  Actions

Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.

Application

Myriocin from Mycelia sterilia has been used as an inhibitor of sphingolipid or ceramide biosynthesis in various studies.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov