Product Name

Phalloidin from Amanita phalloides

General description

Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly.

Purity

≥90%(HPLC)

CAS Number

17466-45-4

Formula

C³⁵H⁴⁸N⁸O¹¹S

Molecular Weight

788.87

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White Powder

l  Biological Information

Biochem/Physiol  Actions

Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly. In rats, this toxin causes death due to liver hemorrhage and cells show abnormal actin clustering. The affinity of phalloidin to actin is not significantly altered after derivatizing fluorescently labelled phalloidin compounds. These compounds can be used to study actin structure and organization within eukaryotic cells.

Application

Phalloidin has been used:

• As a supplement in PEM buffer and dimethyl sulfoxide (DMSO).

• As a drug.

• In immunohistochemistry to stain F-actin.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov