Product Name

Calyculin A from Discodermia calyx

General description

Calyculin A is derived from the marine sponge Discodermia calyx.

Synonym

Calyculin A; Calyculin

Purity

≥90%(HPLC)

CAS Number

101932-71-2

Formula

C⁵⁰H⁸¹N⁴O¹⁵P

Molecular Weight

1009.17

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White Solid

Solubility(25°C)

DMSO

≥10mg/mL

Ethanol

≥10mg/mL

l  Biological Information

Biochem/Physiol  Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

Application

Calyculin A from Discodermia calyx has been used:

•  as an inhibitor of serine-threonine protein phosphatase 2A

•  as an inhibitor of cyclin D1 phosphatase in human breast cancer cells

•  as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov