Product Name

Antimycin A from Streptomyces sp.

General description

Antimycin is produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.

Synonym

Antipiricullin

CAS Number

1397-94-0

Formula

C²⁸H⁴⁰N²O⁹

Molecular Weight

548.633

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Yellow Powder

l  Biological Information

Biochem/Physiol  Actions

Inhibitor of electron transfer at complex III. Induces apoptosis.

Application

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures

• in organello ATP production assay in Trypanosoma brucei cells

• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov