Product Name

Pyocyanin from Pseudomonas aeruginosa

General description

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine.

Synonym

5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

Purity

≥98%(HPLC)

CAS Number

85-66-5

Formula

C¹³H¹⁰N²O

Molecular Weight

210.23

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Blue Powder or Solid

Solubility(25°C)

DMSO

soluble

Ethanol

soluble

l  Biological Information

Biochem/Physiol  Actions

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov