Product Name

Fostriecin sodium salt from Streptomyces pulveraceus

General description

Fostriecin sodium salt is an antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

Synonym

FOSTRIECIN SODIUM

Purity

≥98%(HPLC)

CAS Number

87860-39-7

Formula

C¹⁹H²⁶NaO⁹P

Molecular Weight

452.37

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

l  Biological Information

Biochem/Physiol  Actions

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov