Product Name

Okadaic acid from Prorocentrum concavum

General description

Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum and Dinophysis.

Synonym

OA

Assay

92-100%(HPLC)

CAS Number

78111-17-8

Formula

C⁴⁴H⁶⁸O¹³

Molecular Weight

805

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Solubility(25°C)

DMSO

≥1mg/mL

Ethanol

≥1mg/mL

Water

insoluble

l  Biological Information

Biochem/Physiol  Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

Application

Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor:

•  to inhibit protein phosphatase 2 in spermatocytes culture

•  to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau

•  to treat human embryonic kidney 293T cells (HEK293T) or H4 cells to analyse its effect on fused in sarcoma (FUS) protein

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov