Product Name

Cyclopiazonic acid from Penicillium cyclopium

General description

Cyclopiazonic acid (CPA), a tetramic acid  is synthesized by various Aspergillus and Penicillium species.

Synonym

CPA

Purity

≥98%(HPLC)

CAS Number

18172-33-3

Formula

C²⁰H²⁰N²O³

Molecular Weight

336.38

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to White w/ Yellow Cast powder

Solubility(25°C)

DMSO

soluble

l  Biological Information

Biochem/Physiol  Actions

Inhibits the sarcoplasmic reticulum Ca₂₊-pump.

Application

Cyclopiazonic acid from Penicillium cyclopium has been used:

•  as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)

•  as a component in Ca₂₊-free DMEM/10% fetal bovine serum (FBS)

•  as a reversible inhibitor of the sarco/endoplasmic reticulum Ca₂₊-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking

•  as an endoplasmic reticulum Ca₂₊-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca₂₊ during Ca₂₊-induced Ca₂₊ release (CICR) to inhibit SERCA

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov