Product Name

Globomycin from Streptomyces hagronensis

General description

Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall  synthesis inhibition.

Synonym

Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone, SF 1902

Purity

≥98%(HPLC)

CAS Number

67076-74-8

Formula

C³²H⁵⁷N⁵O⁹

Molecular Weight

655.82

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White Powder

Solubility(25°C)

DMSO

~1mg/mL

l  Biological Information

Biochem/Physiol  Actions

Globomycin was found to inhibit LspA, a lipoprotein signal peptidase. It eliminates the maturation of pro-lipoproteins by inhibition of the enzyme that converts pro-lipoprotein to lipoprotein, acting as a substrate analog of the signal sequence in the outer membrane of Gram-negative bacteria.

l  Storage

Storage temp.

−20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov