Product Name

Violacein from Janthinobacterium lividum

General description

Violacein, a violet pigment, is an indole derivative.

Purity

>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)

CAS Number

548-54-9

Formula

C²⁰H¹³N³O³

Molecular Weight

343.34

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Dark Blue to Very Dark Blue and Purple to Very Dark Purple and Blue-Purple and Purple-Blue Powder

l  Biological Information

Biochem/Physiol  Actions

Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov