Product Name

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis)

General description

Linear polypeptide antibiotic complex.

Synonym

Gramicidine; Gramicidinum

Purity

Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.

CAS Number

1405-97-6

Formula

C⁹⁹H¹⁴⁰N²⁰O¹⁷

Molecular Weight

1882.332

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off white Powder or crystalline powder

l  Biological Information

Biochem/Physiol  Actions

Linear polypeptide antibiotic mixture of gramicidin A, B, C, and D. Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid b.Gramicidin D, a channel-forming ionophore that flip-flops slowly across the membrane is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.

Application

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) has been used as a control to measure the rate of diffusion of protonated β-lactams through the lipid b in liposome swelling assay. It has also been used as an analyte for the purpose of infrared laser desorption or ionization from silicon.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov