Product Name

Phleomycin from Streptomyces verticillus

General description

Phleomycin is a structurally related form of the antibiotic, bleomycin.

Synonym

Phleomycin complex

CAS Number

11006-33-0

Purity

This purified phleomycin is mainly composed of phelomycin D1 (terminal amine is agmatine) in a copper chelate and  hydrochloride salt form.

Formula

C⁵¹H⁷⁵N¹⁷O²¹S²

Molecular Weight

1326.379

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Light blue powder

l  Biological Information

Biochem/Physiol  Actions

Phleomycin is a structurally related form of the antibiotic, bleomycin. Phleomycin blocks S-phase entry in the cell cycle. While phleomycin can damage DNA, like bleomycin, it is not used as an anticancer agent, but rather as a selection agent. The RAD6 DNA repair gene is essential for phleomycin resistance in mutant yeast.

l  Storage

Storage temp.

2-8°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov