Product Name

LY-294002 hydrochloride

General description

LY-294002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates  of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Synonym

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

Purity

≥98.0%(HPLC)

CAS Number

934389-88-5

Formula

C¹⁹H¹⁷NO3 · HCl

Molecular Weight

343.8

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25℃)

DMSO

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Specific cell permeable phosphatidylinositol 3-kinase inhibitor. LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates  of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Application

LY-294,002 hydrochloride has been used in the inhibition of:

•  phosphoinositide 3-kinase (PI3K) in human lung cancer cell line

•  autophagy in mesenchymal stem cells (MSCs).

•  serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

l  Storage

Storage  temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov