Product Name

Zaragozic acid A trisodium salt

General description

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiaesqualene synthase.

Synonym

L-694,599;Squalestatin

Purity

≥95.0%(HPLC)

CAS Number

144541-82-2

Formula

C³⁵H⁴³O¹⁴Na³

Molecular Weight

756.68

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to faint yellow/tan lyophilized powder

Solubility(25℃)

DMSO

≥5 mg/mL

l  Biological Information

Biochem/Physiol   Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiaesqualene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Application

Zaragozic acid A trisodium salt has been used as:

•  a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing

•   a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells

•  a cholesterol synthesis inhibitor in T cells

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov