l General Information |
Product Name | U 18666A |
General description | Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase). |
Synonym | (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 3039-71-2 |
Formula | C25H41NO2·HCl | Molecular Weight | 424.06 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Beige Solid |
Solubility(25℃) | Water | ≥10mg/mL |
l Biological Information |
Biochem/Physiol Actions | Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase). Weak inhibitor of hedgehog (hh) signaling. |
Application | U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
