Product Name

Triacsin C from Streptomyces sp.

General description

Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase.

Synonym

2,4,7-Undecatrienal nitrosohydrazone; WS1228A

Purity

≥95.0%(HPLC)

CAS Number

76896-80-5

Formula

C¹¹H¹⁷N³O

Molecular Weight

207.27

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Off-white to Light Yellow Solid

l  Biological Information

Biochem/Physiol   Actions

Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.

Application

Triacsin C was found to induce maturation in mouse and Xenopus oocytes in the absence of long chain acyl-CoA synthetase. Triacsin C can also block palmitoylation of the G-protein alpha S subunit6. Furthermore, triacsin C can stabilize1-oleoyl-2-acetyl-sn-glycerol (OAG) and enhance perilipin 3 recruitment to the endoplasmic reticulum (ER) in mouse cells7.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov