l General Information |
Product Name | SR1848 |
General description | SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the of CyclinD1 and E1, which results in inhibition of cell proliferation. |
Synonym | 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione; CDI 3238389;ML180 |
Purity | ≥98.0%(HPLC) | CAS Number | 863588-32-3 |
Formula | C20H25ClN4O2 | Molecular Weight | 388.89 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | white to beige solid |
Solubility(25℃) | DMSO | ~5 mg/mL(warmed) |
l Biological Information |
Biochem/Physiol Actions | SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
