l General Information |
Product Name | Sandoz 58-035 |
General description | Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. |
Synonym | SA 58-035; 3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenethyl]propanamide |
Purity | ≥98.0%(HPLC) | CAS Number | 78934-83-5 |
Formula | C30H47NOSi | Molecular Weight | 465.79 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White Solid |
Solubility(25℃) | DMSO | ≥5mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture.1 It does not affect the triglyceride metabolism by the gut.2 |
Application | Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
