l General Information |
Product Name | S-2E |
General description | HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. |
Synonym | (S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 155730-92-0 |
Formula | C22H25NO4 | Molecular Weight | 367.44 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | white solid |
Solubility(25℃) | DMSO | ≥5mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively. |
Application | S-2E may be used in cell signaling studies. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
