Product Name

Cerivastatin sodium salt hydrate

General description

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation.

Synonym

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic   acid sodium salt hydrate, Rivastatin hydrate

Purity

≥98.0%(HPLC)

CAS Number

143201-11-0 (anhydrous)

Formula

C²⁶H³³FNNaO⁵ · xH²O

Molecular Weight

481.53 (anhydrous basis)

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to tan Solid

Solubility(25℃)

Water

≥5mg/mL

l  Biological Information

Biochem/Physiol   Actions

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

Application

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov