Product Name

BMS-303141

General description

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL).

Synonym

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1′-biphenyl]-3-yl)-benzenesulfonamide

Purity

≥98.0%(HPLC)

CAS Number

943962-47-8

Formula

C¹⁹H¹⁵Cl²NO⁴S

Molecular Weight

424.3

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

white to beige solid

Solubility(25℃)

DMSO

≥15mg/mL

l  Biological Information

Biochem/Physiol   Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

Application

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov