l General Information |
Product Name | SC 19220 |
General description | SC 19220 is a competitive antagonist of prostaglandin E receptors. |
Synonym | 2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 19395-87-0 |
Formula | C16H14N3O3Cl | Molecular Weight | 331.75 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White Solid |
Solubility(25℃) | DMSO | ≥5mg/mL |
Water | insoluble |
l Biological Information |
Biochem/Physiol Actions | EP1 Prostanoid receptor antagonist SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α.SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6. |
Application | SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
