Product Name

Prostaglandin I2 sodium salt

General description

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells.

Synonym

(5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI2-Na, Prostacyclin sodium salt

Purity

≥96.0%(HPLC)

CAS Number

61849-14-7

Formula

C²⁰H³¹NaO⁵

Molecular Weight

374.45

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

white to off-white solid

Solubility(25℃)

Ethanol

≥35mg/mL

Water

Slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase.[1] Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

Application

Prostaglandin I2 sodium salt has been used:

•   in the preparation of stock solution for platelet washing procedure

•   as supplement in platelet-rich-plasma, for platelet preparation

•   to prevent platelet activation

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov