Product Name

L-161,982

General description

L-161,982 is a potent EP4 receptor antagonist

Synonym

N-[[4′-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1"-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

Purity

≥98.0%(HPLC)

CAS Number

147776-06-5

Formula

C³²H²⁹F³N⁴O⁴S²

Molecular Weight

654.72

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to beige Solid

Solubility(25℃)

DMSO

≥5mg/mL

l  Biological Information

Biochem/Physiol   Actions

L-161,982 is a potent EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov