Product Name

15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

General description

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase.

Synonym

(S)-15-HETE, 15(S)-HETE; (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid

Purity

≥97.0%(HPLC)

CAS Number

54845-95-3

Formula

C²⁰H³²O³

Molecular Weight

320.47

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solution

l  Biological Information

Biochem/Physiol   Actions

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov