Product Name

12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic   acid

General description

Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of   relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca₂₊-activated K₊ currents in coronary microvascular smooth muscle.

Synonym

(S)-12-HETE

Purity

≥95.0%(HPLC)

CAS Number

54397-83-0

Formula

C20H32O3

Molecular Weight

320.47

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Clear colorless Liquid

l  Biological Information

Biochem/Physiol   Actions

Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca₂₊ activated K₊ currents in coronary microvascular smooth muscle.

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX or activity has been reported in various carcinomas including prostate carcinoma.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov