l General Information |
Product Name | NCTT-956 |
General description | NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity. |
Synonym | N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide |
Purity | ≥97.0%(NMR) | CAS Number | 438575-88-3 |
Formula | C17H15N3O4S | Molecular Weight | 357.38 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Light orange to dark orange Solid |
Solubility(25℃) | DMSO | ~5mg/mL |
l Biological Information |
Biochem/Physiol Actions | NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
