l General Information |
Product Name | HZ52 |
General description | HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase (Enzyme IC50 = 1.3 and 2.0 mM, respectively). |
Synonym | 2-[[4-([1,1′-Biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-octanoic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 1077626-51-7 |
Formula | C24H26ClN3O2S | Molecular Weight | 456 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to beige Solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
l Biological Information |
Biochem/Physiol Actions | HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase (Enzyme IC50 = 1.3 and 2.0 mM, respectively). HZ52 inhibits carrageenan-induced pleurisy and PAF-induced lethal shock in mouse. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
