l General Information |
Product Name | CJ-13610 |
General description | CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). |
Synonym | Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide |
Purity | ≥98.0%(HPLC) | CAS Number | 179420-17-8 |
Formula | C22H23N3O2S | Molecular Weight | 393.5 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | white to tan solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
l Biological Information |
Biochem/Physiol Actions |
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice. |
Application | CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
