Product Name

6-(2-Propargyloxyphenyl)hexanoic acid

General description

PPOH is a selective inhibitor of epoxygenation catalyzed by CYP450 isozymes.

Synonym

PPOH

Purity

≥98.0%(HPLC)

CAS Number

206052-01-9

Formula

C¹⁵H¹⁸O³

Molecular Weight

246.3

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

l  Biological Information

Biochem/Physiol   Actions

PPOH is a synthetic, acetylenic fatty acid and a selective inhibitor of arachidonate epoxygenation reactions catalyzed by certain microsomal cytochrome P450 (CYP) enzymes.1,2 PPOH inhibits the reaction of epoxide formation (IC50 of 90 µM) at arachidonate positions 11 and 12 by CYP4A2 and CYP4A3 isozymes. PPOH does not inhibit the ω-hydroxylation reaction of CYP4A1 leading to the formation of 20-HETE. Arachidonate metabolism studies using inhibitors such as PPOH may be useful in elucidating the role of metabolites in regulating renal function and hypertension.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov