l General Information |
Product Name | Tenidap |
General description | Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. |
Synonym | CP 66248; (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide |
Purity | ≥97.0%(HPLC) | CAS Number | 120210-48-2 |
Formula | C14H9ClN2O3S | Molecular Weight | 320.75 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Faintly Yellow to dark Yellow Solid |
Solubility(25℃) | DMSO | Slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC50 value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC50 values are 1.2 and > 30μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC50 = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
