Product Name

Meloxicam sodium salt hydrate

General description

Meloxicam sodium salt hydrate is a non-steroidal anti-inflammatory drug (NSAID).

Purity

≥98.0%(HPLC)

CAS Number

71125-39-8 (anhydrous)

Formula

C¹⁴H¹²N³NaO⁴S² · xH²O

Molecular Weight

373.38 (anhydrous basis)

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Light Yellow to Dark Yellow Solid

Solubility(25℃)

DMSO

≥5mg/mL

l  Biological Information

Biochem/Physiol   Actions

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID) that shows 300-fold selectivity for cyclooxygenase-2 (COX-2) vs cyclooxygenase-1 (COX-1). Meloxicam has been shown to abolish thymulin-induced increases of cytokines and NGF in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro.

Application

Meloxicam sodium salt hydrate has been used:

•   as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor

•   as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures

•   as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)

•   to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein in RAW246.7 cells

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov