l General Information |
Product Name | Cyclophilin A human |
Synonym | CyP |
Assay | ≥95% (SDS-PAGE), recombinant, expressed in E. coli; ≥0.3 mg/mL |
CAS Number | 95076-93-0 | MDL number | MFCD00130885 |
Suitability | BioReagent |
l Physical and Chemical Information |
Appearance | buffered aqueous solution |
l Biological Information |
Biochem/Physiol Actions | Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al. |
Preparation Note | Composed of amino acids 1-165 plus an N-terminal 20 amino acid His-tag; Solution in 20mM Tris, pH 8.0, containing 20 mM NaCl, 0.5 mM DTT and 10% glycerol. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
