Product Name

Carbonic Anhydrase from bovine erythrocytes

Synonym

Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase from bovine erythrocytes

Assay

≥95% (SDS-PAGE), specific activity ≥3,500 W-A units/mg protein; ≥85% protein basis (biuret)

CAS Number

9001-03-0

MDL number

MFCD00081467

Suitability

BioReagent

l Physical and Chemical Information

Appearance

 lyophilized powder

Solubility(25°C)

deionized water: >10 mg/mL

l Biological Information

Biochem/Physiol Actions

Carbonic Anhydrase is a zinc-containing enzyme that catalyzes the reversible conversion of carbon dioxide to bicarbonate. One of its main physiological roles is to maintain the acid-base balance in blood and other tissues. Lack of carbonic anhydrase results in carbonic anhydrase type II deficiency syndrome, which is an autosomal recessive disease that causes osteopetrosis, renal tubular acidosis and brain calcifications.

Application

Carbonic anhydrase, from bovine erythrocytes, is used to create carbon dioxide capture systems and to research various purification techniques . Carbonic anhydrase is also used to study acid-base regulation in fish and carbonic anhydrase type II deficiency syndrome.

Unit Definition

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0°C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

l Storage

Storage temp.

2-8°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov